Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

Eur J Med Chem. 2020 Mar 1:189:112081. doi: 10.1016/j.ejmech.2020.112081. Epub 2020 Jan 20.

Abstract

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained extensive exploration due to its unique structure features and multiple promising biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and toxicology of celastrol in the past ten years. We hope this review would be helpful to get a better grasp of the progresses in the field and provide constructive suggestions for the further study of celastrol.

Keywords: Cancer; Celastrol; Diabetes; Inflammatory; Medicinal chemistry; Obese; Pharmacology and toxicology; Toxicity; Tripterygium wilfordii hook F..

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Drug-Related Side Effects and Adverse Reactions / prevention & control*
  • Humans
  • Pentacyclic Triterpenes
  • Structure-Activity Relationship
  • Tripterygium / chemistry*
  • Triterpenes / adverse effects
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Pentacyclic Triterpenes
  • Triterpenes
  • celastrol